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TSO cites Mark Shea's post on Calvinism (specifically the facet of personal assurance of salvation) which is worth reading in its entirety. He goes on to comment:
"I can certainly see that part of the attraction of Calvinism. Interestingly, the evangelical at Internet Monk writes, 'I’d far prefer the out and out Roman view of 'assurance,' plainly stated as something you can’t have with certainty, than the advice to look at my own life for evidence I’m a real Christian. As Catholic convert and commentator Mark Shea says, 'I became more secure in my relationship with God once I was no longer certain I was going to heaven.' This is where we end up when we self-reference assurance.'"In my view (as a non-theologian who spent 15 adult years in a Reformed congregation before returning to the Catholic Church), the emphasis on personal assurance of one's own salvation (actually more common in Baptist and other traditions) is a weakness of Reformed churches, though not a fatal one. It appears to be a response to the natural concern about one's own eternal fate that, in Catholics, might have its expression in a paranoia about falling into sin characterized by an over-scrupulous adherence to the less-critical aspects of faith and moral teaching (such as 'I can't miss Mass on Sunday unless I'm so sick I absolutely can't drag myself out of bed.').
But, Calvinism is all about God's Sovereignty. Rightly understood, Calvinist teaching about "irresistible grace" and "perseverance of the saints" expresses this emphasis on the sovereignty of God rather than the felt experience of man. That doesn't mean this belief is always expressed in the life of the believer. Just as a Calvinist might try mightily to feel saved, so a Catholic might strive to convince himself that he had made a "good" confession. Both miss the point. It is the mercy of God in the redemption of Christ in which we hope. His love for us is stronger than our sin, so long as we place ourselves in his hands. So we do the best we can and trust him, whose nature is Love, to make up for our incapabilities.
[By the way, for a really excellent treatment of the five hallmarks of Calvinism and the ways they are like or different from Catholic teaching, I recommend "A Tiptoe Through TULIP" by Jimmy Akin.]